Ion Channels/Arrhythmia Journal Club Schedule (2005-2006)

Fourth Thursdays, 11 AM - 12:30 PM
Room 116 Service Memorial Institute
1300 University Avenue
Jonathan C. Makielski, MD, Professor, Medicine (Cardiovascular), Chair
Contact info@cvrc.wisc.edu for further information

Fall 2005

Sep. 22, 2005
Jonathan C. Makielski, MD, Professor, Medicine (Cardiovascular)

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins. Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavillet B, Apotheloz F, Cordonier S, Staub O, Rotin D, Abriel H. Related Articles, Links Am J Physiol Cell Physiol. 2005 Mar;288(3):C692-701.

Oct. 27, 2005
Bin Ye, Ph.D., Assistant Scientist, Medicine (Cardiovascular)

A Novel Mechanism of Modulation of Hyperpolarization-activated Cyclic Nucleotide-gated Channels by Src Kinase. Zong X, Eckert C, Yuan H, Wahl-Schott C, Abicht H, Fang L, Li R, Mistrik P, Gerstner A, Much B, Baumann L, Michalakis S, Zeng R, Chen Z, Biel M. J Biol Chem. 2005 Oct 7;280(40):34224-34232. Epub 2005 Aug 3.

Nov. 17, 2005 (one week early due to holiday)
Brian Delisle, Ph.D., Postdoctoral Fellow, Medicine (Cardiovascular); former Trainee, Training Program in Translational Cardiovascular Science

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Long SB, Campbell EB, Mackinnon R. Science. 2005 Aug 5;309(5736):897-903.

Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Long SB, Campbell EB, Mackinnon R. Science. 2005 Aug 5;309(5736):903-8.

Dec. 15, 2005 (one week early due to Christmas holiday)
Nian-Qing Shi, Ph.D., Assistant Scientist, Medicine (Cardiovascular)

Switching the Sorting Mode of Membrane Proteins from Cotranslational Endoplasmic Reticulum Targeting to Posttranslational Mitochondrial Import. Emi Miyazaki, Yuichiro Kida, Katsuyoshi Mihara, and Masao Sakaguchi. Molecular Biology of the Cell April 2005 (16), 1788–1799.

Targeting, Import, and Dimerization of a Mammalian Mitochondrial ATP Binding Cassette (ABC) Transporter, ABCB10 (ABC-me)* . Solomon A. Graf, Sarah E. Haigh, Erica D. Corson, and Orian S. Shirihai. Journal of Biological Chemistry 2004 Oct 8; 279, (41): 42954–42963.

Spring 2006

Jan. 26, 2006
Jason D. Foell, Graduate Student, Physiology and Trainee, Training Program in Translational Cardiovascular Science

Ahnak is critical for cardiac Ca(v)1.2 calcium channel function and its ?-adrenergic regulation. Emi Hannelore Haase, Julio Alvarez, Daria Petzhold, Anke Doller, Joachim Behlke, Jeanette Erdmann, Roland Hetzer, Vera Regitz-Zagrosek, Guy Vassort, Ingo Morano, FASEB December 2005, J 19, 1969-1977.

The AHNAKs are a class of giant propeller-like proteins that associate with calcium channel proteins of cardiomyocytes and other cells. Akihiko Komuro, Yutaka Masuda, Koichi Kobayashi, Roger Babbitt, Murat Gunel, Richard A. Flavell, and Vincent T. Marchesi PNAS March 23, 2004, 101(12), 4053–4058

Feb. 23, 2006
Cancelled.

Mar. 23, 2006
Gail A. Robertson, Ph.D., Associate Professor, Physiology

The S4-S5 linker directly couples voltage sensor movement to the activation gate in the hERG K+ channel. Tania Ferrer, Jason Rupp, David R. Piper & Martin Tristani-Firouzi JBC Papers in Press. Published on March 8, 2006 online.

Apr. 27, 2006
Elon Roti Roti Graduate Student, Cellular and Molecular Biology and former Trainee, Training Program in Translational Cardiovascular Science

Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking . Sun HY, Liu XD, Xiong QJ, Shikano S, and Li M. Journal of Biological Chemistry 281 (9): 5877-5884 Mar 3 2006.

Function recovery after chemobleaching (FRAC): Evidence for activity silent membrane receptors on cell surface. Sun HY, Shikano S, Xiong QJ, Xiong Q, and Li M Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16964-16969 Nov 30 2004.

May 25, 2006
Hector H. Valdivia, MD, Ph.D. Professor, Physiology

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. Wu X, Zhang T, Bossuyt J, Li X, McKinsey TA, Dedman JR, Olson EN, Chen J, Brown JH, Bers DM. J Clin Invest. 2006 Mar;116(3):675-82. .

Commentary: Dichotomy of Ca2+ in the heart: contraction versus intracellular signaling. Molkentin JD. J Clin Invest. 2006 Mar;116(3):623-6.

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